The Notorious Accutane Purge and How to Avoid It

What is the Accutane Purge?

The Accutane purge — that dreaded flare-up in breakouts for the first 4 to 8 weeks of treatment — happens because Isotretinoin speeds up skin cell turnover, bringing all the "under-the-skin" stuff to the surface. These are pimples that probably would have surfaced anyways, but are now brought up faster.

While it's not always avoidable, there are ways to minimize the severity or even skip it entirely for some people:

Start with Lower Doses

• Lower initial dose: Dermatologists can prescribe a low dose (e.g., 0.25 mg/kg/day) at the beginning, gradually increasing over a few weeks. The Clear Health Micro-dose Protocol may also reduce the risk of a purge as there is a slower increase in cellular turnover with a smaller dose.

• This gives your skin time to adjust and can reduce the risk or severity of a purge.


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Transition From a Short Course of Topicals or Antibiotics

• Topicals: Retinoids (like adapalene) or benzoyl peroxide for a few weeks beforehand may help normalize skin turnover before starting Accutane.

• Oral antibiotics: Some derms prescribe a short course before or during early Accutane treatment to calm inflammation and reduce bacteria, potentially softening the purge. However, tetracycline antibiotics are contraindicated to Accutane and should not be taken at the same time – consult your dermatologist to best determine what kind of plan might work for you.

Low-dose Prednisone (Corticosteroids) Can Help For Severe Purges

• Prednisone is a systemic corticosteroid — an anti-inflammatory that can help calm severe breakouts quickly.

• Prednisone can reduce severe inflammation (especially cystic acne) and prevent scarring.

• It can help patients stick with Accutane if the purge becomes unbearable.

⚠ Caution

Prednisone has its own side effects: weight gain, mood swings, insomnia, and more. It's not a long-term solution and can suppress the immune system. Always consult your dermatologist to consider whether prednisone may be an option for you as it is not a treatment that should be taken long term.

Antihistamines can sometimes help

• Antihistamines – medications typically used for allergies - won’t stop the purge, but they can help you feel more comfortable and manage symptoms like redness, itching, and swelling. They're safe to take with Accutane in most cases — just run it by your derm or pharmacist to check for any personal contraindications.

Ultimately, the notorious “Accutane Purge” is something that can be mitigated but is not necessarily 100% avoidable. Fortunately, the Accutane Purge is usually temporary, and for many patients it goes away quickly. It’s not the best part of the treatment process, but typically what lies on the other side for many people is crystal clear skin.