Iso-Clear IntroAs seen in Vogue
Iso-Clear Intro
Iso-Clear Intro

Now my skin is clear, and my confidence is higher than ever!

- BROOKE S.

Month 0
Month 9
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ACCUTANE (ISOTRETINOIN)

Rx

Micro-dose Protocol

A gentler, low-dose isotretinoin protocol that targets acne at the source while minimizing side effects and maintaining consistency.

  • Potentially minimize side effects
  • Prescriptions, labs, and more – delivered
  • Get evaluated in 24 hours

$591st month then $109/mo

Evaluation + medication included (if prescribed)

Who is best suited for the Micro-dose Protocol?

The Microdose Protocol is ideal for people with persistent mild to moderate acne, oily skin, or recurring breakouts who want long-term skin clarity with a gentler, lower-dose approach.

iPLEDGE and safety requirements

iPLEDGE is an FDA-required safety program for Accutane treatment. Depending on eligibility and sex assigned at birth, requirements may include monthly check-ins, pregnancy testing for female patients, bloodwork monitoring, and completing iPLEDGE confirmation steps before medication can be prescribed each month.

Why choose Clear Health for Accutane treatment?

Accutane treatment can feel overwhelming — from monthly monitoring to pharmacy coordination, and safety requirements. Clear Health simplifies the process with provider evaluations in as little as 24 hours, guided support throughout treatment, and medication delivered directly to your door in 3–5 days.

PROTOCOL IMPORTANT INFORMATION: Low-dosing Isotretinoin (Accutane) is considered a form of off-label prescribing. The FDA requires that prescription drugs go through a clinical testing process to establish that they’re safe and effective to treat a particular condition. Healthcare providers generally may prescribe the drug for an unapproved use when they judge that it is medically appropriate for their patient. This type of prescribing is called “off-label” prescribing. Off-label prescribing practices are sometimes validated by clinical experience and research and may be a widely recognized clinical practice. Clear Health™ affiliated providers have the discretion to prescribe drugs off-label based on a patient’s unique medical history, symptoms, and preferences.
Eligible patients may be prescribed Accutane branded Isotretinoin or its bio-equivalent generic versions depending on pharmacy selection, insurance coverage, and pharmacy stock. The physician overseeing treatment will determine which medications (or substitutions) may be most appropriate.

The “Hollywood dose” of Accutane.
A gentler approach - now available online.

The “Hollywood dose” of Accutane. A gentler approach - now available online.

Vogue

“There was a time when all of the models and actors in New York were microdosing Accutane,”

- Dr. Daniel Belkin, MD, board-certified dermatologist

NewBeauty

There is a new contender in the game:
Clear Health’s Micro-Dose Accutane Protocol, a low-dose form of Accutane treatment

Dermatology Times

“Micro-dose Accutane, or alternative dosing Accutane, is a well-known secret of dermatologists”

- Dr. Aaron Farberg, Clear Health Medical Director

Vogue

“There was a time when all of the models and actors in New York were microdosing Accutane,”

- Dr. Daniel Belkin, MD, board-certified dermatologist

NewBeauty

There is a new contender in the game:
Clear Health’s Micro-Dose Accutane Protocol, a low-dose form of Accutane treatment

Dermatology Times

“Micro-dose Accutane, or alternative dosing Accutane, is a well-known secret of dermatologists”

- Dr. Aaron Farberg, Clear Health Medical Director

The “Hollywood Dose” of Accutane for Clearer Skin

For mild to moderate acne, aggressive treatments aren’t always necessary.

Micro-dose Accutane uses lower, controlled doses to reduce breakouts, balance oil, and support clearer skin - while helping minimize common side effects.

Designed for consistent results with a gentler experience.

0%of patients saw
acne reduction*

*Plewig et al., J Dtsch Dermatol Ges. 2004 - inflammatory lesions reduced 87–94% in low-dose isotretinoin groups. PMID: 16281880. Individual results vary.

Who this treatment is best suited for

  • Persistent mild to severe acne
  • Acne that hasn’t responded to other treatments
  • Frequent, persistent, or cystic breakouts

Your provider will evaluate your skin and determine if this treatment is appropriate for you.

THE HOLLYWOOD SECRET

What Hollywood insiders have quietly known for years

High-dose Accutane works - but the side effects can be intense. For years, those with access to top dermatologists were prescribed a different approach: lower, continuous doses that clear skin just as effectively, potentially without the harsh trade-offs.

This is the Hollywood Dose - now accessible to everyone through Clear Health. No waiting rooms. No referrals. Just smarter treatment.

Hollywood Comparison

All candidates for Isotretinoin (Accutane) treatment must be enrolled into the FDA's iPLEDGE program, which mandates certain requirements including pregnancy testing and contraceptive-use for female patients that can get pregnant. Additional requirements during treatment include bloodwork lab orders and monthly check-ins with a physician.

IMPORTANT SAFETY INFORMATION FOR ISOTRETINOIN (GENERIC ACCUTANE): Isotretinoin (Accutane) must not be used by patients who are or may become pregnant. There is an extremely high risk that severe birth defects will result if pregnancy occurs while taking Isotretinoin (Accutane) in any amount, even for short periods of time. Potentially any fetus exposed during pregnancy can be affected. There are no accurate means of determining whether an exposed fetus has been affected. Read moreabout serious warnings and safety info.
Why patients choose
Clear Health
Dermatologist evaluations in < 24 hrs
Access 24/7 support throughout treatment
Medication delivered to your door in 3–5 days
Filled through specialized pharmacies
Ongoing progress monitoring & adjustments
★★★★★
★★★★★

4.6/5 BASED ON 30,000+ PATIENTS

Month 0
Month 3
★★★★★
★★★★★
" When you’ve tried everything and Finally find something that works 🙌 @helloclearhealth "Read More
Month 0
Month 5
★★★★★
★★★★★
" I’ve struggled with acne since I was 14, and Clear Health made my second Accutane journey easy and stress-free. Everything was online, my meds came right to my door, and within months my skin cleared completely. I’ve never felt more confident. "Read More
Month 0
Month 5
★★★★★
★★★★★
" A year ago, my acne was at its worst. After six months of treatment with Clear Health, my skin is clear, healthy, and I finally feel confident again. "Read More
Month 0
Month 4
★★★★★
★★★★★
" I had been on different antibiotics and topicals for almost a year before discovering Accutane. Three months in and I was already starting to see great results. I can’t wait to finish treatment! "Read More
Month 0
Month 4
★★★★★
★★★★★
" I was on accutane for the standard protocol and I had no problems at all. I just finished my treatment. If I had any issues or questions they responded fairly quickly. I would recommend this to anyone who had any problems with acne or their skin. "Read More
Month 0
Month 3
★★★★★
★★★★★
" Before starting, my skin was stubborn with constant breakouts that never went away no matter what I tried, from topicals to antibiotics and skincare trends. After a few months on Accutane, my skin completely transformed. I have no active acne now, my face feels smooth, my confidence is up, and I no longer worry about new breakouts. "Read More
Month 0
Month 4
★★★★★
★★★★★
" Now that I no longer have to stress about any upcoming breakouts, I can see my true-self when I look in the mirror. "Read More
Month 0
Month 3
★★★★★
★★★★★
" Accutane has been a life changer. It has changed my confidence and my entire life. I am so happy that I found you!! "Read More
Month 0
Month 5
★★★★★
★★★★★
" I haven’t had a breakout in months, my skin is smoother, clearer, and I feel so much more confident. Clear Health made the whole process seamless and stress-free. "Read More
Month 0
Month 4
★★★★★
★★★★★
" As a content creator, my skin is always on display. Breakouts made me anxious about filming, but Clear Health changed that. Everything was quick, online, and personalized. A few months later, my skin was clear — and so was my confidence. "Read More
Month 0
Month 4
★★★★★
★★★★★
" I’d tried everything for my acne — nothing lasted. On a road trip, I started Clear Health’s micro-dosing Accutane, and within months, my skin completely transformed. "Read More
Month 0
Month 4
★★★★★
★★★★★
" Clear Health made the process simple and stress-free. In just three months, my skin’s smoother, less oily, and breakout-free — finally clear after years of struggling. "Read More
Month 0
Month 7
★★★★★
★★★★★
" I needed something easy and effective. Clear Health made Accutane simple and guided me through it. Now my skin’s clear, smooth, and I feel confident every day. "Read More
Month 0
Month 4
★★★★★
★★★★★
" My acne was at its worst as I started my career, but Clear Health made treatment easy and stress-free. Now my skin is clear, and my confidence is higher than ever! "Read More

*Results and timelines may vary from person to person.

The Science Behind Micro-dosing Accutane

A low-dose approach to acne management that supports clearer skin with better tolerance over time.

01

Gently reduces oil production

Low-dose isotretinoin decreases excess sebum without aggressive suppression.

View study →
02

Gradually normalizes skin turnover

Improves cell renewal over time to prevent clogged pores.

View study →
03

Lower dose. Fewer side effects.

Designed to manage acne with fewer side effects than conventional dosing.

View study →
1

Gently reduces oil production

Low-dose isotretinoin decreases excess sebum without aggressive suppression.

View study →
3

Lower dose. Fewer side effects.

Designed to manage acne with fewer side effects than conventional dosing.

View study →
Iso-Clear Cream Swatch
2

Gradually normalizes skin turnover

Improves cell renewal over time to prevent clogged pores.

View study →
Clinical references are based on isotretinoin. Individual results may vary. Not recommended during pregnancy or if planning pregnancy.
Always consult a qualified medical professional before starting treatment.
Clinical references are based on isotretinoin. Individual results may vary. Not recommended during pregnancy or if planning pregnancy.
Real results, over time
A guided micro-dose Accutane journey designed to deliver long-term skin clearing while helping minimize the harsh side effects commonly associated with traditional high-dose treatment.
Month 0ADAM G.VERIFIED PATIENT
Month 4

I haven't had those painful strawberry breakouts since starting with Clear Health, it's completely changed my skin.

I haven't had those painful strawberry breakouts since starting with Clear Health, it's completely changed my skin.

*Treatment plans are based on individual evaluation. Results and timelines may vary from person to person.

Month 1–3: Adjustment phase
Your skin starts adapting
Your skin begins adapting as oil production slows and internal changes start. Results may be subtle, but this phase lays the foundation for long-term clarity.
Focus is on preparing your skin for deeper transformation.

Clear, doctor-guided Accutane treatment

Access personalized treatment, prescription management, and ongoing support - all in one streamlined experience.

Simple, transparent pricing

Clear, upfront pricing with no hidden fees or surprise charges, so you always know exactly what's included in your treatment plan.

Ongoing monitoring & treatment adjustments

Track your acne journey with progress photos, treatment check-ins, and access to your intake history throughout care. If your doctor recommends changing or adjusting your treatment, it's included at no additional consultation cost.

No insurance required

Get access to expert acne treatment without insurance, referrals, or in-person appointments.

Flexible payment options available

Choose a payment option that fits your budget. Affirm financing with 0% APR options is available on eligible plans.

Access across all 50 states

Get expert dermatology care from anywhere in the U.S., with no in-person visits required.

Evaluation + Medication Included

Monthly

Everything for your treatment, in one price

Evaluation + Medication Included
$59for the first month then $109/mo

Billed monthly

INCLUDES
First month’s medication included if prescribed - just pay first month’s shipping*

*No shipping fees from second month onwards.

Get a treatment plan in <24 hours
Get medication delivered directly to you in 3–5 days
Unlimited support from clinical team
How long will your Micro-dose Accutane course actually last?Micro-dose treatment isn't time-based — your real course length depends on your body weight and target cumulative dose (150–220 mg/kg). Enter your weight to see an estimate.
lbskg
30mg / 3 days
40mg / 3 days

*Your clinician will confirm your personalised treatment plan during consultation.

Enter your weight above to see your estimated course length.

*Based on a target range of 150-220 mg/kg. Individual results may vary.

Find the protocol built for your skin.

Two clinically proven paths to clear skin. Compare what each protocol includes, then choose the one that fits your needs and timeline.

Standard Protocol Box
ACCUTANE (ISOTRETINOIN)

Standard Protocol

Treatment length6-9 months
  • Moderately severe to severe acne, or anyone who hasn't responded to other treatments
  • Rapid, aggressive clearance
  • Shorter overall treatment timeline
  • Insurance and cash-pay options for medication
  • 1st month's medication included on 6-month plans if filling through Clear Health Pharmacy

Starting at $59 /mo

Micro-dose Protocol Box
ACCUTANE (ISOTRETINOIN)

Micro-dose Protocol

Treatment length18-24 months
  • Mild to moderate acne, sensitive skin, or anyone who wants results without aggressive side effects
  • More comfortable and predictable experience
  • Potentially minimize treatment side effects
  • Consistent monthly cost
  • Monthly medications are included on all plans

$59 for 1st month then $109/mo

Timelines above are typical ranges. See your personalized timeline →

Why patients see better acne results with Clear Health

Designed to support you through every step of your treatment journey.
CONVENIENT

Everything online, from getting clear to staying clear.

iPLEDGE items, labs, prescriptions, skincare and more, all managed in your digital portal.
Detailed video and SMS onboarding with your clinical team so you never miss a beat.
App Mockup
AFFORDABLE

Get treated at 1/3 the cost.

Micro-dose Isotretinoin (Generic Accutane) has traditionally been costly because it is not covered by insurance plans. Thru Clear Health™, no insurance is required and we're able to deliver this novel treatment at a fraction of the in-office cost.

1st month's order delivered for FREE if approved - just pay $7.99 shipping and handling.

CLEAR HEALTH™ MICRO-DOSE PROTOCOL
Starting at $59/ monthEvaluation + medication
IN-OFFICE
$400 / monthEvaluation + medication
Clear Health Package
ACCESSIBLE

We'll set all the reminders so you don't have to.

Automated monthly SMS check-ins so you're always on top of treatment.
Around-the-clock access to your physician.
24/7 access to Nurse Advice line.
Accessible Care

It’s time for your follow-up evaluation to receive your next supply of treatment!

Break Capsule

Cumulative dosage: 150-220 mg/kg

Get started in <24 hours

  • Ongoing monitoring & adjustments
  • iPLEDGE guidance and compliance support
  • Unlimited messaging with the clinical care team
How we Compare

Clear Health

Simple, transparent pricing

Starting at $89.92
(includes evaluations & medication)

First month medication free

Medical adjustments included

Traditional Care

Expensive and unpredictable

$200+ to get started

$200+ for medication

Extra fees for changes

Filling with Clear Health vs.filling with Local Pharmacies

Local pharmacies treat isotretinoin like any other prescription. We built Clear Health so yours is handled by specialists, on your iPLEDGE window, at a price you can plan for.

iPLEDGE-synced refills

We track it and ship before it closes, every month.

Cash pricing, no surprises

Built for cash-pay isotretinoin, including our lower-cost micro-dose protocol.

Dermatology-trained pharmacists

Real isotretinoin specialists with 20+ years of pharmacist experience.

Video thumbnail

Micro-dose Accutane:

Overcoming Pharmacy and Insurance Hurdles

Micro-dose Accutane: Overcoming Pharmacy and Insurance Hurdles
0:00 / 0:00
Video thumbnail

Micro-dose Accutane:

Overcoming Pharmacy and Insurance Hurdles

Micro-dose Accutane: Overcoming Pharmacy and Insurance Hurdles
0:00 / 0:00
The right care for a powerful treatment
Accutane requires more than just a prescription - it demands expert oversight, structured guidance, and consistent monitoring every step of the way.
Board-Certified Dermatologists
Our team includes recognized, credentialed clinicians dedicated to increasing access to care.
Acne Solution Innovators
Our experts are at the forefront of the latest acne research, bringing fresh insights to help transform skin health.
Patient-Centric Approach
The patient experience sits at the center of everything we do.
Dr. Aaron Farberg
Clear Health™ Medical Director
Mohs surgeon and former consultant dermatologist to the NY Yankees.
Icahn School of Medicine at Mount Sinai
Clinical Assistant Professor at UNT Health Science Center

FAQs

Find out more about Micro-dose Protocol
What is Microdose Accutane?
Microdose Accutane (isotretinoin) is a prescription acne treatment that uses a lower daily dose of isotretinoin than traditional Accutane. It is often prescribed for mild to moderate acne, long-term acne control, or for patients who want a more gradual treatment approach. It’s known for effective acne clearing with fewer side effects, and is usually taken for 18–24 months. The lower dose can help reduce common side effects such as dry lips, dry skin, and irritation while still providing long-term improvement in acne.
What does treatment involve?
Accutane treatment includes monthly follow-ups, iPLEDGE enrollment, and routine monitoring during treatment. Patients who can get pregnant must also complete monthly pregnancy tests, answer iPLEDGE questions, and follow contraception requirements, along with a mandatory 30-day waiting period before starting treatment.
What is iPLEDGE?
iPLEDGE is the FDA-required safety program for Accutane treatment in the U.S. It helps prevent pregnancy during treatment because Accutane can cause severe birth defects. All patients receive an iPLEDGE ID during treatment.
What is the 30-day waiting period?
Patients who can get pregnant must wait 30 days after approval before receiving their first prescription and complete two pregnancy tests in a medical setting.
How is Clear Health™ different?
Clear Health™ makes Accutane treatment simpler with dermatologist review in under 24 hours, online follow-ups, automated reminders for iPLEDGE and labs, and ongoing support throughout treatment.

Blogs

Blog Image

Micro-dose Protocol – A Game Changer in Acne Treatment

Written by Michael Chang

Ever since we launched Clear Health with a focus on Accutane, we knew that there would be a subset of acne-sufferers that we wouldn’t be able to serve given some .....

Low Dose Accutane Acne Medications

A One-Stop Shop for your Journey

Introducing
Iso-Clear topical bottle
Topical Isotretinoin SystemRx

Isoclear™

Starts at$50/mo

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Exclusive 1st month's medication included on select plans. Just pay shipping.
Standard protocol treatment box
Accutane (Isotretinoin)Rx

Standard Protocol

Evaluations start at$59/mo

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Evaluations + medications included on all plans.
Micro-dose protocol treatment boxMicro-dose protocol treatment box
Accutane (Isotretinoin)Rx

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1st month starts at$59

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Jojoba Oil Cleanser
Skincare Item

Jojoba Oil Cleanser

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Lightweight Moisturizer
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Lightweight Moisturizer

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Compounded Topical
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Compounded Topical

from$30/mo

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Spironolactone + Topical
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Spironolactone + Topical

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Doxycycline + Topical
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$40/mo

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At-Home LFT + Lipid Panel Bloodwork Kit
Supporting Product

At-Home LFT + Lipid Panel Bloodwork Kit

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Home Pregnancy Tests (6 ct)
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Home Pregnancy Tests (6 ct)

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Aquaphor® (3 ct)
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Aquaphor® (3 ct)

$30

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Real people with real results

4.6/5 BASED ON 30,000+ PATIENTS

Customer support is on it

D S.

Customer support is on it! Always helping me with things I need and ask. Also, their quick replies are amazing. I m... Read More

My experience has been great so far

Amanda B.

My experience has been great so far! Easy to message my doctor with any questions and I was able to get on Accutane so... Read More

Great Company! Wonderful Services!

D HB.

Very fast and helpful assistance from all staff members. Customer service is always there to assist me and the doctors... Read More

Clear Health has been very responsive…

BIBI.

Clear Health has been very responsive to my questions in a short time span as well as having a very courteous approach.

Amazing and revolutionary acne treatment

Sanjana D.

Its a great and cheap way to get one of the most expensive treatments for acne out there. The support is amazing, they... Read More

Smooth and easy process

MELISS

Smooth and easy process. Especially helpful with clearing hoops like prior authorization and communicating with... Read More

Super responsive customer support

ERICA D.

Super responsive customer support! The experience has been great for my daughter and so much easier than waiting months... Read More

So much easier and quicker than going…

JACKIE M.

So much easier and quicker than going through the in-person experience. This is my 2nd time going on Accutane, and I... Read More

I'm very pleased with Clear Health

Shaban R.

I'm very pleased with Clear Health! Everything was wonderful, from the initial online consultation to the monthly order... Read More

*Individual results vary